Dissecting Semaphorin Signaling
نویسندگان
چکیده
منابع مشابه
Dissecting Semaphorin Signaling
ble for the binding specificities of the semaphorins in situ (Feiner et al., 1997), while the Ig-basic domain also exhibits binding properties. The neuropilins have two N-terminal domains similar to complement binding domains , called CUB domains; two coagulation factor domains ; a C-terminal MAM domain; a transmembrane domain; and a short cytoplasmic tail (see figure). Both Giger et al. (1998)...
متن کاملSemaphorin Signaling in Vertebrate Neural Circuit Assembly
Neural circuit formation requires the coordination of many complex developmental processes. First, neurons project axons over long distances to find their final targets and then establish appropriate connectivity essential for the formation of neuronal circuitry. Growth cones, the leading edges of axons, navigate by interacting with a variety of attractive and repulsive axon guidance cues along...
متن کاملSemaphorin signaling in morphogenesis: found in translation.
Semaphorins play diverse roles in axon guidance and epithelial morphogenetic cell movements. In this issue of Genes & Development, Nukazuka and colleagues (1025-1036) show that semaphorins regulate Caenorhabditis elegans male tail morphogenesis by stimulating the translation of specific messages, including the actin-depolymerizing enzyme cofilin.
متن کاملSemaphorin Signaling A Little Less Per-Plexin
Recent advances in our understanding of axon guidance during neural development are highlighted by the characterization of several gene families containing members capable of functioning as repellents. These include ephrins, netrins, and semaphorins. Though future work will undoubtedly result in the identification of still more repellents, the wealth of information now in hand concerning the ce...
متن کاملSemaphorin signaling guides cranial neural crest cell migration in zebrafish.
Cranial neural crest cells (NCCs) migrate into the pharyngeal arches in three primary streams separated by two cranial neural crest (NC)-free zones. Multiple tissues have been implicated in the guidance of cranial NCC migration; however, the signals provided by these tissues have remained elusive. We investigate the function of semaphorins (semas) and their receptors, neuropilins (nrps), in cra...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neuron
سال: 1998
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(00)80608-x